Total Syntheses of the Structures Assigned to Denigrins A, B, C, F, and G, 3,4-Diaryl-Pyrrole and -Pyrrolidinone Alkaloids, and the Conversion of Congener B into the Co-metabolite Spirodactylone.
J Nat Prod
; 87(6): 1521-1531, 2024 Jun 28.
Article
en En
| MEDLINE
| ID: mdl-38754059
ABSTRACT
The title marine natural products have been prepared by total synthesis and in the case of congeners 3, 6, and 7 for the first time. Each of these was obtained by manipulation of readily prepared denigrin B (2). The structure, 3, assigned to denigrin C is shown to be incorrect. Reaction of compound 2 with DDQ has led, in high yield, to the related natural product spirodactylone (16), while treating the corresponding permethyl ether 15 with PIFA/BF3·Et2O provides compound 20, embodying an isomeric framework.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pirroles
/
Pirrolidinonas
/
Alcaloides
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article