Prohibitin 2 deficiency in photoreceptors leads to progressive retinal degeneration and facilitated Müller glia engulfing microglia debris.

Zuo, Haoyu; Han, Wenjuan; Wu, Keling; Yang, Haohan; Song, Huiying; Zhang, Zirong; Lai, Yuhua; Pan, Zhongshu; Li, Weihua; Zhao, Ling

Zuo, Haoyu; Han, Wenjuan; Wu, Keling; Yang, Haohan; Song, Huiying; Zhang, Zirong; Lai, Yuhua; Pan, Zhongshu; Li, Weihua; Zhao, Ling.

Zuo H; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Han W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Wu K; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Yang H; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.
Song H; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Zhang Z; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Lai Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Pan Z; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of
Li W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. Electronic address: liweihua@gzzoc.com.
Zhao L; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. Electronic address: zhaoling6@mail.sysu.edu.cn.

Exp Eye Res ; 244: 109935, 2024 Jul.

Article en En | MEDLINE | ID: mdl-38763352

Asunto(s)

Células Ependimogliales; Microglía; Células Fotorreceptoras de Vertebrados; Prohibitinas; Degeneración Retiniana; Animales; Ratones; Modelos Animales de Enfermedad; Electrorretinografía; Células Ependimogliales/metabolismo; Células Ependimogliales/patología; Ratones Endogámicos C57BL; Ratones Noqueados; Microglía/metabolismo; Microglía/patología; Fagocitosis/fisiología; Células Fotorreceptoras de Vertebrados/patología; Células Fotorreceptoras de Vertebrados/metabolismo; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Proteínas Represoras/deficiencia; Degeneración Retiniana/metabolismo; Degeneración Retiniana/patología; Degeneración Retiniana/fisiopatología; Tomografía de Coherencia Óptica

Palabras clave

Microglia; Müller glia; Phagocytosis; Phb2; Photoreceptor; Progressive retinal degeneration

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Degeneración Retiniana / Microglía / Células Fotorreceptoras de Vertebrados / Células Ependimogliales / Prohibitinas Límite: Animals Idioma: En Año: 2024 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google