Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.
Proc Natl Acad Sci U S A
; 121(22): e2322617121, 2024 May 28.
Article
en En
| MEDLINE
| ID: mdl-38771873
ABSTRACT
Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges in older adulthood would be associated with lower microstructural integrity of the locus coeruleus. Leveraging in vivo histological methods from quantitative MRI-magnetic transfer saturation-we provide evidence that older age is associated with lower locus coeruleus integrity. Critically, we demonstrate that an exploitation bias in older adulthood, assessed with a foraging task, is sensitive and specific to lower locus coeruleus integrity. Because the locus coeruleus is uniquely vulnerable to Alzheimer's disease pathology, our findings suggest that aging, and a presymptomatic trajectory of Alzheimer's related decline, may fundamentally alter decision-making abilities in later life.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
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Locus Coeruleus
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Imagen por Resonancia Magnética
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Toma de Decisiones
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2024
Tipo del documento:
Article