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An efficient debromination technique using PMHS with a number of ligands containing different functional groups.
Mian, Md Yeunus; Mondal, Prithu; Sharmin, Dishary; Pandey, Kamal P; Rashid, Farjana; Rezvanian, Sepideh; Golani, Lalit K; Tiruveedhula, V V N Phani Babu; Rajaratnam, Vilashini; Mirza, Shama P; Chan, John D; Witkin, Jeffrey M; Cook, James M.
  • Mian MY; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Mondal P; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Sharmin D; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Pandey KP; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Rashid F; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Rezvanian S; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Golani LK; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Tiruveedhula VVNPB; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Rajaratnam V; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Mirza SP; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Chan JD; Department of Chemistry, University of Wisconsin-Oshkosh, Oshkosh, WI-54901.
  • Witkin JM; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
  • Cook JM; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI-53211.
ARKIVOC ; 2021(5): 171-188, 2021.
Article en En | MEDLINE | ID: mdl-38774148
ABSTRACT
Herein is described the strategy to debrominate different aryl bromides selectively, using polymethylhydrosiloxane (PMHS) which tolerates a variety of functional groups. Key elements of this approach include the use of catalytic Pd(OAc)2 and the correct equivalents of polymethylhydrosiloxane (PMHS), in conjunction with aqueous KF. The present reaction process provides a strategic tool for the synthesis of a number of medicinally important molecules.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article