Your browser doesn't support javascript.
loading
Sputum interleukin-6 level as a marker of severity during acute chest syndrome in children with sickle cell disease.
Mayrand, Lara; Elie, Juliette; Pinhas, Yael; Rignault-Bricard, Rachel; Taylor, Melissa; Brice, Joséphine; de Montalembert, Mariane; Heilbronner, Claire; Beranger, Agathe; Angyalosy, Sofia; Chhun, Stephanie; Maciel, Thiago Trovati; Hermine, Olivier; Allali, Slimane.
  • Mayrand L; Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163, Université Paris Cité, Paris, France.
  • Elie J; Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
  • Pinhas Y; Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163, Université Paris Cité, Paris, France.
  • Rignault-Bricard R; Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
  • Taylor M; Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
  • Brice J; Laboratory of Excellence GR-Ex, Paris, France.
  • de Montalembert M; Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163, Université Paris Cité, Paris, France.
  • Heilbronner C; Laboratory of Excellence GR-Ex, Paris, France.
  • Beranger A; Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
  • Angyalosy S; Laboratory of Excellence GR-Ex, Paris, France.
  • Chhun S; Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
  • Maciel TT; Laboratory of Excellence GR-Ex, Paris, France.
  • Hermine O; Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
  • Allali S; Laboratory of Excellence GR-Ex, Paris, France.
Br J Haematol ; 205(1): 329-334, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38783629
ABSTRACT
Acute chest syndrome (ACS) is a leading cause of morbimortality in sickle cell disease (SCD). In this prospective observational study, we investigated sputum interleukin-6 (IL-6) level as an ACS severity marker during 30 ACS episodes in 26 SCD children. Sputum IL-6 levels measured within the first 72 h of hospitalisation for ACS were significantly higher in patients with oxygen requirement ≥2 L/min, ventilation (invasive and/or non-invasive) length ≥5 days, bilateral and/or extensive opacities on chest X-ray or erythrocytapheresis requirement. Sputum IL-6 could serve as an ACS severity marker to help identify patients requiring targeted anti-inflammatory treatments such as tocilizumab.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esputo / Índice de Severidad de la Enfermedad / Biomarcadores / Interleucina-6 / Síndrome Torácico Agudo / Anemia de Células Falciformes Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esputo / Índice de Severidad de la Enfermedad / Biomarcadores / Interleucina-6 / Síndrome Torácico Agudo / Anemia de Células Falciformes Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Año: 2024 Tipo del documento: Article