Comprehensive overview of analytical and bioanalytical methodologies for the opioid analgesics - Tramadol and combinations.
Anal Biochem
; 692: 115579, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38797485
ABSTRACT
Synthetic opioids like Tramadol are used to treat mild to moderate pain. Its ability to relieve pain is about a tenth that of morphine. Furthermore, Tramadol shares similar effects on serotonin and norepinephrine to several antidepressants known as serotonin-norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine and duloxetine. The present review paper discusses the recent developments in analytical methods for identifying drugs in pharmaceutical preparations and toxicological materials, such as blood, saliva, urine, and hair. In recent years, a wide variety of analytical instruments, including capillary electrophoresis, NMR, UV-visible spectroscopy, HPTLC, HPLC, LC-MS, GC, GC-MS, and electrochemical sensors, have been used for drug identification in pharmaceutical preparations and toxicological samples. The primary quantification techniques currently employed for its quantification in various matrices are highlighted in this research.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tramadol
/
Analgésicos Opioides
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article