A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder.
J Clin Psychiatry
; 46(3 Pt 2): 53-8, 1985 Mar.
Article
en En
| MEDLINE
| ID: mdl-3882682
ABSTRACT
The efficacy of fluoxetine was evaluated in depressed patients in double-blind imipramine- and placebo-controlled clinical trials. Fluoxetine produced greater improvement than placebo on all major efficacy parameters and was comparable to imipramine with respect to the primary indicators of depression. Fluoxetine had significantly less associated anticholinergic effects, dizziness, drowsiness, somatosensory disturbance, and excessive sweating than imipramine. Although nausea occurred more frequently in fluoxetine patients, it was generally mild and well tolerated. A significantly smaller percentage of fluoxetine than imipramine patients terminated therapy because of adverse experiences.
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Banco de datos:
MEDLINE
Asunto principal:
Propilaminas
/
Fluoxetina
/
Trastorno Depresivo
/
Atención Ambulatoria
/
Imipramina
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1985
Tipo del documento:
Article