Adenoid Cystic carcinoma of minor salivary glands (AdCCmSG): a multidisciplinary update.
Expert Rev Anticancer Ther
; 24(7): 567-580, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38832770
ABSTRACT
INTRODUCTION:
Adenoid cystic carcinoma of minor salivary glands (AdCCmSG) represents a 'rarity in the rarity,' posing a clinical challenge in lack of standardized, evidence-based recommendations. At present, AdCCmSG management is mostly translated from major salivary gland cancers (MSGCs). Ideally, AdCCmSG diagnostic-therapeutic workup should be discussed and carried out within a multidisciplinary, high-expertise setting, including pathologists, surgeons, radiation oncologists and medical oncologists. AREAS COVERED The present review provides an overview of epidemiology and pathologic classification. Moreover, the most recent, clinically relevant updates in the treatment of AdCCmSG (Pubmed searches, specific guidelines) are critically discussed, aiming to a better understanding of this rare pathologic entity, potentially optimizing the care process, and offering a starting point for reflection on future therapeutic developments. EXPERT OPINION The management of rare cancers is often hindered by limited data and clinical trials, lack of evidence-based guidelines, and hardly represented disease heterogeneity, which cannot be successfully tackled with a 'one-size-fits-all' approach. Our goal is to address these potential pitfalls, providing an easy-to-use, updated, multidisciplinary collection of expert opinions concerning AdCCmSG management as of today's clinical practice. We will also cover the most promising future perspectives, based on the potential therapeutic targets highlighted within AdCCmSG's molecular background.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glándulas Salivales Menores
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Neoplasias de las Glándulas Salivales
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Carcinoma Adenoide Quístico
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article