The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death.
Food Chem Toxicol
; 190: 114791, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38849045
ABSTRACT
AIM:
Bortezomib is a proteasome inhibitor antineoplastic agent that was the first to be approved for cancer treatment. One of bortezomib's most prominent dose-limiting effects is nephrotoxicity; the underlying mechanism is believed to be oxidative stress. Chrysin is a compound found actively in honey and many plant species and stands out with its antioxidant properties. The present study aimed to determine the ameliorative effects of chrysin in bortezomib-induced nephrotoxicity. MATERIAL-METHOD:
Thirty-five male Wistar rats were divided into control, BTZ, CHR, BTZ + CHR25, and BTZ + CHR50. Biochemical, molecular, Western blot, and histological methods analyzed renal function indicators, oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, and damage pathways.RESULTS:
Chrysin decreased oxidative stress by reducing oxidants (MDA) and increasing antioxidants (SOD, CAT, Gpx, GSH, Nrf-2, HO-1, NQO1). Chrysin reduced endoplasmic reticulum stress by decreasing ATF-6, PERK, IRE1, and GRP-78 levels. Chrysin reduced inflammation damage by inhibiting the NF-κB pathway. Chrysin exhibited protective properties against apoptotic damage by decreasing Bax and Caspase-3 levels and increasing Bcl-2 levels. In addition, chrysin improved renal function and structural integrity and exhibited healing properties against toxic damage in tissue structure.CONCLUSION:
Overall, chrysin exhibited an ameliorative effect against bortezomib-induced nephrotoxicity.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Flavonoides
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Apoptosis
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Estrés Oxidativo
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Estrés del Retículo Endoplásmico
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Bortezomib
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Inflamación
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Enfermedades Renales
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article