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A morphological analysis of calcium hydroxylapatite and poly-l-lactic acid biostimulator particles.
McCarthy, Alec D; Hartmann, Christian; Durkin, Alan; Shahriar, Shatil; Khalifian, Saami; Xie, Jingwei.
  • McCarthy AD; Medical Affairs, Merz Aesthetics, Raleigh, North Carolina, USA.
  • Hartmann C; R&D, Merz Aesthetics GmbH, Frankfurt, Germany.
  • Durkin A; Ocean Drive Plastic Surgery, Vero Beach, Florida, USA.
  • Shahriar S; University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Khalifian S; SOM Aesthetics, Encinitas, California, USA.
  • Xie J; University of Nebraska Medical Center, Omaha, Nebraska, USA.
Skin Res Technol ; 30(6): e13764, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38853456
ABSTRACT
Injectable fillers, pivotal in aesthetic medicine, have evolved significantly with recent trends favoring biostimulators like calcium hydroxylapatite (CaHA-CMC; Radiesse, Merz Aesthetics, Raleigh, NC) and poly-l-lactic acid (PLLA; Sculptra Aesthetics, Galderma, Dallas, TX). This study aims to compare the particle morphology of these two injectables and examine its potential clinical implications. Utilizing advanced light and scanning electron microscopy techniques, the physical characteristics of CaHA-CMC and PLLA particles were analyzed, including shape, size, circularity, roundness, aspect ratio, and quantity of phagocytosable particles. The findings reveal several morphological contrasts CaHA-CMC particles exhibited a smooth, homogenous, spherical morphology with diameters predominantly ranging between 20 and 45 µm, while PLLA particles varied considerably in shape and size, appearing as micro flakes ranging from 2 to 150 µm in major axis length. The circularity and roundness of CaHA-CMC particles were significantly higher compared to PLLA, indicating a more uniform shape. Aspect ratio analysis further underscored these differences, with CaHA-CMC particles showing a closer resemblance to circles, unlike the more oblong PLLA particles. Quantification of the phagocytosable content of both injectables revealed a higher percentage of phagocytosable particles in PLLA. These morphological distinctions may influence the tissue response to each treatment. CaHA-CMC's uniform, spherical particles may result in reduced inflammatory cell recruitment, whereas PLLA's heterogeneous particle morphology may evoke a more pronounced inflammatory response.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Poliésteres / Durapatita / Rellenos Dérmicos Límite: Humans Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Poliésteres / Durapatita / Rellenos Dérmicos Límite: Humans Idioma: En Año: 2024 Tipo del documento: Article