The Blastulation Rate Is Negatively Associated With Euploid Rate.
J Obstet Gynaecol Can
; 46(8): 102586, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38878821
ABSTRACT
OBJECTIVES:
To study the association between the blastulation rate, the presence of 1 pronucleus (1PN) zygotes, and the ploidy of the cohort of blastocysts.METHODS:
A cross-sectional study using the existing databases of 2 university fertility centres in Canada. We included 345 cycles from 235 couples who underwent next-generation sequencing preimplantation genetic testing for the detection of aneuploidy in the study.RESULTS:
A total of 1456 blastocysts were biopsied. In multivariate analysis, only female age and the number of 1PN/2PN embryos showed a negative association with euploid ratio. Surprisingly, when the analysis was limited to cycles with no delayed blastulation, the blastulation rate was also negatively associated with the euploid ratio.CONCLUSIONS:
This study sheds some light on the stages of early embryo development. Further study on the mechanisms governing embryo development and the different cell cycle checkpoints in embryo development is warranted.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diagnóstico Preimplantación
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
País como asunto:
America do norte
Idioma:
En
Año:
2024
Tipo del documento:
Article