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Genetic variants related to insulin metabolism are associated with gestational diabetes mellitus.
Bhushan, Ravi; Haque, Shafiul; Gupta, Rakesh Kumar; Rani, Anjali; Diwakar, Amita; Agarwal, Sakshi; Tripathi, Anima; Dubey, Pawan K.
  • Bhushan R; Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
  • Haque S; Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon; Centre of Medical and Bio-Allied Health Sciences Research, Ajman Univer
  • Gupta RK; Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
  • Rani A; Department of Obstetrics and Gynaecology, Institute of Medical Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
  • Diwakar A; Department of Obstetrics and Gynaecology, Institute of Medical Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
  • Agarwal S; Department of Obstetrics and Gynaecology, Institute of Medical Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
  • Tripathi A; Zoology Section, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
  • Dubey PK; Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India. Electronic address: pawandubey1981@gmail.com.
Gene ; 927: 148704, 2024 Nov 15.
Article en En | MEDLINE | ID: mdl-38885821
ABSTRACT
The current study sought to investigate the associations of common genetic risk variants with gestational diabetes mellitus (GDM) risk in the north Indian population and to evaluate their utility in identifying GDM cases. A case-control study, including 300 pregnant women, was included, and clinical and pathological information was collected. The amplification-refractory mutation system (ARMS) was used for genotyping four single nucleotide polymorphisms (SNPs), namely FTO (rs9939609), PPARG2 (rs1801282), SLC30A8 (rs13266634), and TCF7L2 (rs12255372). The odds ratio and confidence interval were determined for each SNP in different genetic models. Further, attributable risk, population penetrance, and relative risk were also calculated. The risk allele A of FTO (rs9939609) poses a two times higher risk of GDM (p = 0.02, OR = 2.5). The CG and GG genotypes of PPARG2 (rs1801282) have half a lower risk of GDM. In SLC30A8 (rs13266634), the recessive model analysis showed a two times higher risk of having GDM, while the recessive model (TT vs. GG + GT) analysis in TCF7L2 (rs12255372) indicates a lower risk of GDM. Finally, the relative risk, population penetrance, and attributable risk for risk allele in all four variants was higher in GDM mothers. All four polymorphisms were found to be significantly associated with BMI, HbA1c, and insulin. Our study first time confirmed a significant association with GDM for four variants, FTO, PPARG2, SLC30A8, and TCF7L2, in the North Indian population.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diabetes Gestacional / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Proteína 2 Similar al Factor de Transcripción 7 / Transportador 8 de Zinc / Insulina Límite: Adult / Female / Humans / Pregnancy País como asunto: Asia Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diabetes Gestacional / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Proteína 2 Similar al Factor de Transcripción 7 / Transportador 8 de Zinc / Insulina Límite: Adult / Female / Humans / Pregnancy País como asunto: Asia Idioma: En Año: 2024 Tipo del documento: Article