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Hyperthyroidism increases the risk of osteoarthritis in individuals aged 60-80 years.
Zhao, Jinlong; Liang, Haodong; Liang, Guihong; Hong, Kunhao; Yang, Weiyi; Luo, Minghui; Zeng, Lingfeng; Liu, Jun.
  • Zhao J; State Key Laboratory of Traditional Chinese Medicine Syndrome/The Second Clinical College of Guangzhou University of Chinese Medicine, No.111, Dade Road, Yuexiu District, Guangzhou, 510405, Guangdong, China.
  • Liang H; Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases/The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China.
  • Liang G; The Research Team On Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.
  • Hong K; State Key Laboratory of Traditional Chinese Medicine Syndrome/The Second Clinical College of Guangzhou University of Chinese Medicine, No.111, Dade Road, Yuexiu District, Guangzhou, 510405, Guangdong, China.
  • Yang W; The Fifth Clinical College of Guangzhou, University of Chinese Medicine, No.12, Jichang Road, Baiyun District, Guangzhou, 510405, Guangdong, China.
  • Luo M; The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou, 510000, China.
  • Zeng L; State Key Laboratory of Traditional Chinese Medicine Syndrome/The Second Clinical College of Guangzhou University of Chinese Medicine, No.111, Dade Road, Yuexiu District, Guangzhou, 510405, Guangdong, China.
  • Liu J; Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases/The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China.
Sci Rep ; 14(1): 13924, 2024 06 17.
Article en En | MEDLINE | ID: mdl-38886465
ABSTRACT
To elucidate the currently unknown relationship between hyperthyroidism and osteoarthritis (OA). During 2007-2012, 7,433 participants (hyperthyroidism patients = 125; OA patients = 675) were included in the National Health and Nutrition Examination Survey database. We used a weighted multivariable-adjusted logistic regression analysis to assess the association between hyperthyroidism and OA. We also assessed the causality of that relationship using publicly available genome-wide association study data and three Mendelian randomization (MR) analysis methods. The heterogeneity test, pleiotropy test, and leave-one-out tests were used for sensitivity analysis. In this cross-sectional study, after adjusting for potential confounding factors, we found that hyperthyroidism significantly (P = 0.018) increased the risk of OA (odds ratio [OR] = 2.23, 95% confidence interval [CI] = 1.2-4.17). Age-stratified analysis revealed that hyperthyroidism was associated with a greater risk of OA in the 60-80-year-old age group (OR = 2.86, 95% CI = 1.46-5.59, P = 0.002), with no significant association in the 18-59-year-old age group (all P > 0.05). The results of the inverse-variance weighting (IVW) analysis showed that hyperthyroidism increased the risk of OA (OR = 1.23, 95% CI = 1.04-1.46; P = 0.017). The weighted median estimator (WME) and MR-Egger method also confirmed this causal association (OR = 1.27 and OR = 1.32, respectively). The sensitivity analysis results confirmed the reliability of this conclusion. In addition, IVW-based reverse-MR analysis revealed that OA did not increase the risk of hyperthyroidism (OR = 1.02, 95% CI = 0.97-1.08; P = 0.449). Hyperthyroidism is associated with an increased risk of OA, but the underlying pathological mechanism still needs to be clarified in future research.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteoartritis / Estudio de Asociación del Genoma Completo / Hipertiroidismo Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteoartritis / Estudio de Asociación del Genoma Completo / Hipertiroidismo Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2024 Tipo del documento: Article