Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy.
Curr Issues Mol Biol
; 46(6): 5825-5844, 2024 Jun 11.
Article
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| MEDLINE
| ID: mdl-38921019
ABSTRACT
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.
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2024
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