Attitudes, Knowledge, and Risk Perceptions of Patients who Received Elective Genomic Testing as a Clinical Service.

Zoltick, Emilie S; Bell, Megan; Hickingbotham, Madison R; Wu, Ann Chen; Galbraith, Lauren N; LeBlanc, Jessica L; Lu, Christine Y; Leonhard, Jennifer R; Platt, Dylan M; Smith, Hadley Stevens; Green, Robert C; Hajek, Catherine; Christensen, Kurt D

Zoltick, Emilie S; Bell, Megan; Hickingbotham, Madison R; Wu, Ann Chen; Galbraith, Lauren N; LeBlanc, Jessica L; Lu, Christine Y; Leonhard, Jennifer R; Platt, Dylan M; Smith, Hadley Stevens; Green, Robert C; Hajek, Catherine; Christensen, Kurt D.

Zoltick ES; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA.
Bell M; Sanford Imagenetics, Sioux Falls, SD; Augustana University, Sioux Falls, SD. Electronic address: Megan.Bell@SanfordHealth.org.
Hickingbotham MR; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA.
Wu AC; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA; Department of Population Medicine, Harvard Medical School, Boston, MA.
Galbraith LN; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA; Pfizer, Inc., New York, NY.
LeBlanc JL; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA.
Lu CY; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA; Department of Population Medicine, Harvard Medical School, Boston, MA; Kolling Institute, Faculty of Medicine and Health, The University of Sydney and the Northern Sydney Local Health District, Sydney, NSW, Austral
Leonhard JR; Sanford Imagenetics, Sioux Falls, SD.
Platt DM; Sanford Imagenetics, Sioux Falls, SD; Augustana University, Sioux Falls, SD.
Smith HS; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA; Department of Population Medicine, Harvard Medical School, Boston, MA.
Green RC; Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, MA; Ariadne Labs, Boston, MA; The Broad Institute of Harvard and MIT, Cambridge, MA.
Hajek C; Sanford Imagenetics, Sioux Falls, SD; Helix Inc, San Mateo, CA.
Christensen KD; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA; Department of Population Medicine, Harvard Medical School, Boston, MA; The Broad Institute of Harvard and MIT, Cambridge, MA.

Genet Med ; : 101200, 2024 Jun 26.

Article en En | MEDLINE | ID: mdl-38943480

ABSTRACT

ABSTRACT

BACKGROUND:

Elective genomic testing (EGT) is increasingly available clinically. Limited real world evidence exists about attitudes and knowledge of EGT recipients.

METHODS:

After web-based education, patients who enrolled in an EGT program at a rural nonprofit healthcare system completed a survey that assessed attitudes, knowledge, and risk perceptions.

RESULTS:

From August 2020 to April 2022, 5,920 patients completed the survey and received testing. Patients most frequently cited interest in learning their personal disease risks as their primary motivation. Patients most often expected results to guide medication management (74.0%), prevent future disease (70.4%), and provide information about risks to offspring (65.4%). Patients were "very concerned" most frequently about the privacy of genetic information (19.8%) and how well testing predicted disease risks (18.0%). On average, patients answered 6.7 of 11 knowledge items correctly (61.3%). They more often rated their risks for colon and breast cancers as lower rather than higher than the average person, but more often rated their risk for a heart attack as higher rather than lower than the average person (all p<0.001).