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Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG.
Wieczorek, Lindsay; Chang, David; Sanders-Buell, Eric; Zemil, Michelle; Martinez, Elizabeth; Schoen, Jesse; Chenine, Agnes-Laurence; Molnar, Sebastian; Barrows, Brittani; Poltavee, Kultida; Charurat, Man E; Abimiku, Alash'le; Blattner, William; Iroezindu, Michael; Kokogho, Afoke; Michael, Nelson L; Crowell, Trevor A; Ake, Julie A; Tovanabutra, Sodsai; Polonis, Victoria R.
  • Wieczorek L; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Chang D; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Sanders-Buell E; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Zemil M; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Martinez E; Present address: Office of AIDS Research, National Institutes of Health, Rockville, MD, 20852, USA.
  • Schoen J; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Chenine AL; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Molnar S; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Barrows B; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Poltavee K; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Charurat ME; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Abimiku A; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Blattner W; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Iroezindu M; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Kokogho A; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Michael NL; Present address: Integrated Biotherapeutics, Rockville, MD, 20850, USA.
  • Crowell TA; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Ake JA; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
  • Tovanabutra S; U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Resarch, Silver Spring, MD, USA.
  • Polonis VR; Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, USA.
Virol J ; 21(1): 148, 2024 Jun 29.
Article en En | MEDLINE | ID: mdl-38951814
ABSTRACT
The magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria require further characterization. A panel of 50 subtype G and 18 CRF02_AG Nigerian HIV-1 pseudoviruses (PSV) was developed and envelope coreceptor usage, neutralization sensitivity and cross-clade reactivity were characterized. These PSV were neutralized by some antibodies targeting major neutralizing determinants, but potentially important differences were observed in specific sensitivities (eg. to sCD4, MPER and V2/V3 monoclonal antibodies), as well as in properties such as variable loop lengths, number of potential N-linked glycans and charge, demonstrating distinct antigenic characteristics of CRF02_AG and subtype G. There was preferential neutralization of the matched CRF/subtype when PSV from subtype G or CRF02_AG were tested using pooled plasma. These novel Nigerian PSV will be useful to study HIV-1 CRF- or subtype-specific humoral immune responses for subtype G and CRF02_AG.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pruebas de Neutralización / Anticuerpos Anti-VIH / Infecciones por VIH / VIH-1 / Anticuerpos Neutralizantes Límite: Humans País como asunto: Africa Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pruebas de Neutralización / Anticuerpos Anti-VIH / Infecciones por VIH / VIH-1 / Anticuerpos Neutralizantes Límite: Humans País como asunto: Africa Idioma: En Año: 2024 Tipo del documento: Article