Mechanistic insights into the basis of widespread RNA localization.
Nat Cell Biol
; 26(7): 1037-1046, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38956277
ABSTRACT
The importance of subcellular mRNA localization is well established, but the underlying mechanisms mostly remain an enigma. Early studies suggested that specific mRNA sequences recruit RNA-binding proteins (RBPs) to regulate mRNA localization. However, despite the observation of thousands of localized mRNAs, only a handful of these sequences and RBPs have been identified. This suggests the existence of alternative, and possibly predominant, mechanisms for mRNA localization. Here I re-examine currently described mRNA localization mechanisms and explore alternative models that could account for its widespread occurrence.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
Proteínas de Unión al ARN
Límite:
Animals
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article