The relationship between imaging-based body composition parameters and disease prognosis in patients with endometrial cancer.
J Obstet Gynaecol Res
; 50(9): 1566-1573, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38960395
ABSTRACT
BACKGROUND:
Obesity is known as a risk factor for endometrial cancer (EC). Only a few studies investigate the relationship between sarcopenia and sarcopenic obesity and EC. In this study, our aim was to investigate the relationship between the cross-sectional imaging-based body composition parameters and the disease prognosis in low-grade (LG) and high-grade (HG) EC. MATERIALS ANDMETHODS:
We conducted a retrospective study in women diagnosed with low and high-grade EC between January 2014 and May 2022 who had abdominal MRI and thorax CT as a part of routine staging workup. We used the skeletal muscle index (SMI) at the level of the third lumbar vertebra to assess sarcopenia on CT. The T2-weighted sequence at the level of the L2-L3 intervertebral disc is used for visceral fat area (VFA), subcutaneous fat area (SFA), and total fat area (TFA). Two radiologists in consensus, calculated the parameters.RESULTS:
A total of 250 EC patients (144 low-grade EC, 106 high-grade EC).Sarcopenia was observed in 122 (48.8%) patients, and sarcopenic obesity was found in 82 (32.8%) patients. Although there was an increase in VFA in cases with high-grade EC, there was no significant difference in terms of SFA. Additionally, the frequency of sarcopenia and sarcopenic obesity was higher in cases with high-grade EC. There was no association between sarcopenia and age, histological type, FIGO staging, or comorbidity in the univariate analysis. However, BMI was found to be associated with sarcopenia.CONCLUSIONS:
Quantitative radiological measurement of sarcopenia, sarcopenic obesity, and body fat composition can be used as novel parameters in the prediction of disease prognosis in endometrial cancer.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Composición Corporal
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Imagen por Resonancia Magnética
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Neoplasias Endometriales
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Sarcopenia
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Obesidad
Límite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Año:
2024
Tipo del documento:
Article