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Monotherapy with infusion therapies - useful or not?
Rozankovic, Petra Bago; Johansson, Anders; Péter, Klivényi; Milanov, Ivan; Odin, Per.
  • Rozankovic PB; Department of Neurology, Clinical Hospital Dubrava, Avenija Gojka Suska 6, Zagreb, 10000, Croatia. pbago0501@gmail.com.
  • Johansson A; School of Medicine, Catholic University of Croatia, Ilica 242, Zagreb, 10000, Croatia. pbago0501@gmail.com.
  • Péter K; Medical Unit Neurology, Karolinska University Hospital, Stockholm, Sweden.
  • Milanov I; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Odin P; Department of Neurology, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.
Article en En | MEDLINE | ID: mdl-38967810
ABSTRACT
Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with infusion-based therapies could simplify the treatment regimen, provide better medication adherence, reduce adverse events and drug interactions. This review presents the literature data on the efficacy, safety, and achievability of monotherapy with all available infusion-based therapies, including apomorphine, levodopa-carbidopa-intestinal gel (LCIG), levodopa-entacapone-carbidopa intestinal gel (LECIG), and foslevodopa-foscarbidopa (LDp/CDp). In summary, monotherapy is achievable and effective in most patients on intestinal levodopa infusion therapy and in some patients on apomorphine infusion. There is a need for further investigation of monotherapy compared to polytherapy, especially in new pump treatment options (LECIG and LDp/CDp). Future research should reveal which patients on infusion-based therapies could benefit from monotherapy, including identification of potential baseline predictors of achieving monotherapy in patients treated with specific infusion-based therapies.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article