4-Trifluoromethoxy proline: synthesis of stereoisomers and lipophilicity study.
Org Biomol Chem
; 22(39): 7982-7988, 2024 Oct 09.
Article
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| MEDLINE
| ID: mdl-38973538
ABSTRACT
All four stereoisomers of 4-CF3O-proline have been synthesized through a fluorodesulfurization approach using the corresponding 4-hydroxyprolines as starting materials. The investigation of their lipophilicity characteristics and comparison with those of other 4-substituted proline analogs demonstrated a similar impact of CF3 and CF3O groups on log D.
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2024
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