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4-Trifluoromethoxy proline: synthesis of stereoisomers and lipophilicity study.
Logvinenko, Ivan G; Sadkova, Iryna V; Tolmachova, Nataliya A; Shishkina, Svitlana V; Daniliuc, Constantin G; Haufe, Günter; Kondratov, Ivan S.
  • Logvinenko IG; Enamine Ltd, Winston Churchill Str. 78, Kyiv 02094, Ukraine.
  • Sadkova IV; Address V.P. Kukhar Institute of Bioorganic Chemistry & Petrochemistry, National Academy of Sciences of Ukraine, Academician Kukhar Str. 1, Kyiv 02094, Ukraine.
  • Tolmachova NA; Enamine Ltd, Winston Churchill Str. 78, Kyiv 02094, Ukraine.
  • Shishkina SV; Enamine Ltd, Winston Churchill Str. 78, Kyiv 02094, Ukraine.
  • Daniliuc CG; SSI "Institute for Single Crystals" of the National Academy of Sciences of Ukraine, Nauky Ave. 60, Kharkiv 61072, Ukraine.
  • Haufe G; Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, Academician Kukhar Str. Str. 5, Kyiv 02660, Ukraine.
  • Kondratov IS; Organisch-Chemisches Institut, Universität Münster, Corrensstraße 40, Münster 48149, Germany.
Org Biomol Chem ; 22(39): 7982-7988, 2024 Oct 09.
Article en En | MEDLINE | ID: mdl-38973538
ABSTRACT
All four stereoisomers of 4-CF3O-proline have been synthesized through a fluorodesulfurization approach using the corresponding 4-hydroxyprolines as starting materials. The investigation of their lipophilicity characteristics and comparison with those of other 4-substituted proline analogs demonstrated a similar impact of CF3 and CF3O groups on log D.

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article