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SARS-CoV-2 serosurvey across multiple waves of the COVID-19 pandemic in New York City between 2020-2023.
Carreño, Juan Manuel; Wagner, Abram L; Monahan, Brian; Singh, Gagandeep; Floda, Daniel; Gonzalez-Reiche, Ana S; Tcheou, Johnstone; Raskin, Ariel; Bielak, Dominika; Morris, Sara; Fried, Miriam; Yellin, Temima; Sullivan, Leeba; Sordillo, Emilia Mia; Gordon, Aubree; van Bakel, Harm; Simon, Viviana; Krammer, Florian.
  • Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Wagner AL; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Monahan B; Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
  • Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Floda D; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gonzalez-Reiche AS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Tcheou J; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Raskin A; Department of Genetics and Genomic Sciences, ISMMS, New York, NY, USA.
  • Bielak D; Department of Genetics and Genomic Sciences, ISMMS, New York, NY, USA.
  • Morris S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Fried M; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Yellin T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sullivan L; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sordillo EM; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gordon A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • van Bakel H; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Krammer F; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nat Commun ; 15(1): 5847, 2024 Jul 11.
Article en En | MEDLINE | ID: mdl-38992013
ABSTRACT
Sero-monitoring provides context to the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and changes in population immunity following vaccine introduction. Here, we describe results of a cross-sectional hospital-based study of anti-spike seroprevalence in New York City (NYC) from February 2020 to July 2022, and a follow-up period from August 2023 to October 2023. Samples from 55,092 individuals, spanning five epidemiological waves were analyzed. Prevalence ratios (PR) were obtained using Poisson regression. Anti-spike antibody levels increased gradually over the first two waves, with a sharp increase during the 3rd wave coinciding with SARS-CoV-2 vaccination in NYC resulting in seroprevalence levels >90% by July 2022. Our data provide insights into the dynamic changes in immunity occurring in a large and diverse metropolitan community faced with a new viral pathogen and reflects the patterns of antibody responses as the pandemic transitions into an endemic stage.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País como asunto: America do norte Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País como asunto: America do norte Idioma: En Año: 2024 Tipo del documento: Article