Your browser doesn't support javascript.
loading
A near complete genome assembly of the East Friesian sheep genome.
You, Xiaoxiao; Fang, Qinyuan; Chen, Chunhai; Cao, Junwei; Fu, Shaoyin; Zhang, Teng; Wang, Shenyuan; He, Xiaolong; He, Jiangfeng; Zhou, Yang; Wang, Biao; Wang, Liwei; Wang, Zheng; Sun, Tianhao; Yang, Xukui; Te, Rigele; Jian, Jianbo; Zhou, Huanmin; Dai, Yanfeng; Liu, Yongbin.
  • You X; Inner Mongolia University, Hohhot, China.
  • Fang Q; Inner Mongolia University, Hohhot, China.
  • Chen C; BGI Genomics, Shenzhen, China.
  • Cao J; Inner Mongolia Agricultural University, Hohhot, China.
  • Fu S; Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China.
  • Zhang T; Inner Mongolia University, Hohhot, China.
  • Wang S; Inner Mongolia Agricultural University, Hohhot, China.
  • He X; Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China.
  • He J; Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China.
  • Zhou Y; Inner Mongolia University, Hohhot, China.
  • Wang B; Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China.
  • Wang L; Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China.
  • Wang Z; Inner Mongolia University, Hohhot, China.
  • Sun T; Inner Mongolia University, Hohhot, China.
  • Yang X; BGI Genomics, Shenzhen, China.
  • Te R; Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot, China.
  • Jian J; BGI Genomics, Shenzhen, China.
  • Zhou H; Inner Mongolia University, Hohhot, China. huanminzhou@263.net.
  • Dai Y; Inner Mongolia Agricultural University, Hohhot, China. huanminzhou@263.net.
  • Liu Y; Inner Mongolia University, Hohhot, China. daiyf@imu.edu.cn.
Sci Data ; 11(1): 762, 2024 Jul 11.
Article en En | MEDLINE | ID: mdl-38992134
ABSTRACT
Advancements in sequencing have enabled the assembly of numerous sheep genomes, significantly advancing our understanding of the link between genetic variation and phenotypic traits. However, the genome of East Friesian sheep (Ostfriesisches Milchschaf), a key high-yield milk breed, remains to be fully assembled. Here, we constructed a near-complete and gap-free East Friesian genome assembly using PacBio HiFi, ultra-long ONT and Hi-C sequencing. The resulting genome assembly spans approximately 2.96 Gb, with a contig N50 length of 104.1 Mb and only 164 unplaced sequences. Remarkably, our assembly has captured 41 telomeres and 24 centromeres. The assembled sequence is of high quality on completeness (BUSCO score 97.1%) and correctness (QV 69.1). In addition, a total of 24,580 protein-coding genes were predicted, of which 97.2% (23,891) carried at least one conserved functional domain. Collectively, this assembly provides not only a near T2T gap-free genome, but also provides a valuable genetic resource for comparative genome studies of sheep and will serve as an important tool for the sheep research community.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Límite: Animals Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Límite: Animals Idioma: En Año: 2024 Tipo del documento: Article