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Synthesis of Fully Substituted Difluoromethylpyrazoles by Cyclization of Difluoroacetohydrazonoyl Bromides with 2-Acylacetonitriles or Malononitrile.
Wang, Si-Wei; Zhang, Jianzhong; Deng, Zhoubin; Lv, Yuyu; Huang, Danfeng; Wang, Ke-Hu; Wang, JunJiao; Hu, Yulai.
  • Wang SW; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
  • Zhang J; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
  • Deng Z; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
  • Lv Y; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
  • Huang D; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
  • Wang KH; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
  • Wang J; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
  • Hu Y; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
J Org Chem ; 2024 Jul 12.
Article en En | MEDLINE | ID: mdl-38995290
ABSTRACT
A concise and efficient method for the construction of fully substituted difluoromethylpyrazoles is achieved by a cyclization reaction between difluoroacetohydrazonoyl bromides and 2-acylacetonitrile or malononitrile. The method features advantages such as mild reaction conditions, broad substrate scope, good product yields, and high regioselectivity.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article