Robust analysis of microcirculatory flowmotion during post-occlusive reactive hyperemia.
Microvasc Res
; 155: 104715, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39004173
ABSTRACT
BACKGROUND:
Flowmotion analysis of the microcirculatory blood flow is a method to extract information about the vessel regulatory function. It has previously shown promise when applied to measurements during a post-occlusive reactive hyperemia. However, the reperfusion peak and the following monotonic decline introduces false low frequencies that should not be interpreted as rhythmic vasomotion effect.AIM:
To develop and validate a robust method for flowmotion analysis of post-occlusive reactive hyperemia signals.METHOD:
The occlusion-induced reperfusion response contains a typical rapid increase followed by a monotonic decline to baseline. A mathematical model is proposed to detrend this transient part of the signal to enable further flowmotion analysis. The model is validated in 96 measurements on healthy volunteers.RESULTS:
Applying the proposed model corrects the flowmotion signal without adding any substantial new false flowmotion components.CONCLUSION:
Future studies should use the proposed method or equivalent when analyzing flowmotion during post-occlusive reactive hyperemia to ensure valid results.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Flujo Sanguíneo Regional
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Hiperemia
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Microcirculación
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Modelos Cardiovasculares
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2024
Tipo del documento:
Article