Reprogramming Tumor-Associated Macrophages with a Se-Based Core-Satellite Nanoassembly to Enhance Cancer Immunotherapy.
Nano Lett
; 24(29): 9104-9114, 2024 Jul 24.
Article
en En
| MEDLINE
| ID: mdl-39007505
ABSTRACT
Tumor-associated macrophages (TAMs), as the most prevalent immune cells in the tumor microenvironment, play a pivotal role in promoting tumor development through various signaling pathways. Herein, we have engineered a Se@ZIF-8 core-satellite nanoassembly to reprogram TAMs, thereby enhancing immunotherapy outcomes. When the nanoassembly reaches the tumor tissue, selenium nanoparticles and Zn2+ are released in response to the acidic tumor microenvironment, resulting in a collaborative effort to promote the production of reactive oxygen species (ROS). The generated ROS, in turn, activate the nuclear factor κB (NF-κB) signaling pathway, driving the repolarization of TAMs from M2-type to M1-type, effectively eliminating cancer cells. Moreover, the nanoassembly can induce the immunogenic death of cancer cells through excess ROS to expose calreticulin and boost macrophage phagocytosis. The Se@ZIF-8 core-satellite nanoassembly provides a potential paradigm for cancer immunotherapy by reversing the immunosuppressive microenvironment.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Selenio
/
Especies Reactivas de Oxígeno
/
Microambiente Tumoral
/
Macrófagos Asociados a Tumores
/
Inmunoterapia
Límite:
Animals
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article