Modulation of pulmonary oxidative status in methamphetamine-withdrawn rats, comparing the effects of continuous training and NBS superfood supplementation.
Clin Hemorheol Microcirc
; 2024 Jul 18.
Article
en En
| MEDLINE
| ID: mdl-39031345
ABSTRACT
OBJECTIVE:
This study aimed to investigate the effects of six weeks of continuous training and Nutrition Bio-shield (NBS) Superfood Supplementation on the state of oxidative stress by the expression of Nrf2, NOX4, superoxide dismutase, and malondialdehyde genes in the lungs of rats after methamphetamine withdrawal.METHODS:
Forty male Wistar rats were randomly divided into five groups (nâ=â8, per group), undergoing methamphetamine administration (six weeks, 5âmg/kg ip, and once per day) followed by a 21-day withdrawal period. The rats were supplemented NBS superfood at a dosage of 25âg/kg per day for six weeks. The training protocol was 30 minutes of daily continuous training (treadmill running), five days a week for six weeks. The regimen escalated from a pace of 3âm/min for the initial 5 minutes, to 5âm/min for the following 5 minutes, culminating at 8âm/min for the remainder of the session, all at a 0° incline. A one-way analysis of variance was performed to analyze the gene expression of Nrf2, NOX4, MDA, and SOD in the lungs tissue of rats.RESULTS:
The results indicated that, in the experimental groups which underwent continuous training and NBS Superfood supplementation, the expression of the Nrf2 gene exhibited a significant elevation compared to the control group (Pâ<â0.05), while the NOX4, MDA, and SOD genes expression exhibited a significant decline in comparison to the control group (Pâ<â0.05).CONCLUSION:
In general, both exercise interventions and NBS superfood supplementation, when employed separately or in combination after methamphetamine withdrawal, can enhance the state of oxidative stress in the lung.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Año:
2024
Tipo del documento:
Article