PD-L2 mediates tobacco smoking-induced recruitment of regulatory T cells via the RGMB/NF&#954;B/CCL20 cascade.

Guo, Hua; Zhang, Chen; Shen, Yu-Ke; Zhang, Jian-Dong; Yang, Fu-Ying; Liang, Fan; Wang, Wei; Liu, Yu-Tao; Wang, Gui-Zhen; Zhou, Guang-Biao

PD-L2 mediates tobacco smoking-induced recruitment of regulatory T cells via the RGMB/NFκB/CCL20 cascade.

Guo, Hua; Zhang, Chen; Shen, Yu-Ke; Zhang, Jian-Dong; Yang, Fu-Ying; Liang, Fan; Wang, Wei; Liu, Yu-Tao; Wang, Gui-Zhen; Zhou, Guang-Biao.

Guo H; State Key Laboratory of Molecular Oncology & Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Zhang C; School of Life Sciences and Engineering, Handan University, Handan, Hebei Province, 056005, China.
Shen YK; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences & University of Chinese Academy of Sciences, Beijing, 100101, China.
Zhang JD; State Key Laboratory of Molecular Oncology & Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Yang FY; Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Liang F; Shanxi Bethune Hospital Affiliated with Shanxi Academy of Medical Sciences, Taiyuan, Shanxi Province, 030032, China.
Wang W; State Key Laboratory of Molecular Oncology & Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Liu YT; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences & University of Chinese Academy of Sciences, Beijing, 100101, China.
Wang GZ; School of Basic Medicine, Weifang Medical University, Shandong, 261000, China.
Zhou GB; Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Cell Biol Toxicol ; 40(1): 56, 2024 Jul 23.

Article en En | MEDLINE | ID: mdl-39042313

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas; Quimiocina CCL20; Neoplasias Pulmonares; FN-kappa B; Proteína 2 Ligando de Muerte Celular Programada 1; Linfocitos T Reguladores; Linfocitos T Reguladores/inmunología; Linfocitos T Reguladores/metabolismo; Humanos; FN-kappa B/metabolismo; Animales; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patología; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/inmunología; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/patología; Carcinoma de Pulmón de Células no Pequeñas/inmunología; Proteína 2 Ligando de Muerte Celular Programada 1/metabolismo; Proteína 2 Ligando de Muerte Celular Programada 1/genética; Quimiocina CCL20/metabolismo; Quimiocina CCL20/genética; Ratones; Fumar Tabaco/efectos adversos; Transducción de Señal; Línea Celular Tumoral; Masculino; Femenino

Palabras clave

CCL20; NSCLC; PD-L2; RGMB; Tobacco smoke; Tregs

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: FN-kappa B / Linfocitos T Reguladores / Carcinoma de Pulmón de Células no Pequeñas / Quimiocina CCL20 / Proteína 2 Ligando de Muerte Celular Programada 1 / Neoplasias Pulmonares Límite: Animals / Female / Humans / Male Idioma: En Año: 2024 Tipo del documento: Article

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