Highly Efficient Asymmetric [3+2] Cycloaddition Promoted by Chiral Aziridine-Functionalized Organophosphorus Compounds.
Molecules
; 29(14)2024 Jul 11.
Article
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| MEDLINE
| ID: mdl-39064862
ABSTRACT
The asymmetric [3+2] cycloaddition of azomethine ylides generated from the corresponding imino ester-to-trans-ß-nitrostyrene catalysis by chiral aziridine-containing phosphines and phosphine oxides is described. Of the sixteen stereoisomers that could be formed as a result of the title reaction, three were formed, two of which were obtained in an enantiomerically enriched or pure form, and one in a racemic form. One of the products underwent epimerization under basic reaction conditions.
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2024
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Article