Cardiac fibroblasts: answering the call.
Am J Physiol Heart Circ Physiol
; 327(3): H681-H686, 2024 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-39093000
ABSTRACT
Cardiac fibroblasts play a pivotal role in maintaining heart homeostasis by depositing extracellular matrix (ECM) to provide structural support for the myocardium, vasculature, and neuronal network and by contributing to essential physiological processes. In response to injury such as myocardial infarction or pressure overload, fibroblasts become activated, leading to increased ECM production that can ultimately drive left ventricular remodeling and progress to heart failure. Recently, the American Journal of Physiology-Heart and Circulatory Physiology issued a call for papers on cardiac fibroblasts that yielded articles with topics spanning fibroblast physiology, technical considerations, signaling pathways, and interactions with other cell types. This mini-review summarizes those articles and places the new findings in the context of what is currently known for cardiac fibroblasts and what future directions remain.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Matriz Extracelular
/
Fibroblastos
/
Miocardio
Límite:
Animals
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article