Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure.
Sci Adv
; 10(32): eado7538, 2024 Aug 09.
Article
en En
| MEDLINE
| ID: mdl-39110791
ABSTRACT
Chronic wounds affect ~2% of the U.S. population and increase risks of amputation and mortality. Unfortunately, treatments for such wounds are often expensive, complex, and only moderately effective. Electrotherapy represents a cost-effective treatment; however, its reliance on bulky equipment limits its clinical use. Here, we introduce water-powered, electronics-free dressings (WPEDs) that offer a unique solution to this issue. The WPED performs even under harsh conditions-situations wherein many present treatments fail. It uses a flexible, biocompatible magnesium-silver/silver chloride battery and a pair of stimulation electrodes; upon the addition of water, the battery creates a radial electric field. Experiments in diabetic mice confirm the WPED's ability to accelerate wound closure and promote healing by increasing epidermal thickness, modulating inflammation, and promoting angiogenesis. Across preclinical wound models, the WPED-treated group heals faster than the control with wound closure rates comparable to treatments requiring expensive biologics and/or complex electronics. The results demonstrate the WPED's potential as an effective and more practical wound treatment dressing.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vendajes
/
Cicatrización de Heridas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article