The Cytokine Storm of Multicentric Castleman Disease.
Adv Exp Med Biol
; 1448: 459-467, 2024.
Article
en En
| MEDLINE
| ID: mdl-39117833
ABSTRACT
As described throughout this book, different triggers can elicit a variety of different cytokine storm disorders that share overlapping clinical features (Fig. 31.1). Even within a particular cytokine storm disorder, multiple different triggers can elicit the syndrome. Like HLH, multicentric Castleman disease (MCD) serves as a great example of this as it can be caused by a viral infection, neoplastic cell population, or an unknown cause. Furthermore, the idiopathic subtype of MCD (iMCD) provides one of the first examples of a cytokine storm disorder that could be abrogated with targeted neutralization of a single cytokine when inhibition with the anti-interleukin-6 (IL-6) receptor monoclonal antibody tocilizumab was shown to effectively treat iMCD in the 1990s. Of course, this "iMCD treatment," tocilizumab, has been used in a variety of cytokine storm settings over the last 30+ years.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Castleman
/
Anticuerpos Monoclonales Humanizados
/
Síndrome de Liberación de Citoquinas
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article