CD137 (4-1BB) and T-Lymphocyte Exhaustion.
Clin Cancer Res
; : OF1-OF3, 2024 Aug 09.
Article
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| MEDLINE
| ID: mdl-39120463
ABSTRACT
CD137 (4-1BB) costimulation results in the potent activation of antitumor T lymphocytes and elicits antitumor efficacy that is synergistic with anti-PD(L)1 checkpoint inhibitors, especially when using bispecific constructs. Emerging experimental evidence indicates that 4-1BB ligation prevents and may revert T-cell exhaustion. See related article by Jeon et al., p. XX.
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