Hybrid Integrated Wearable Patch for Brain EEG-fNIRS Monitoring.

ABSTRACT

Synchronous monitoring electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) have received significant attention in brain science research for their provision of more information on neuro-loop interactions. There is a need for an integrated hybrid EEG-fNIRS patch to synchronously monitor surface EEG and deep brain fNIRS signals. Here, we developed a hybrid EEG-fNIRS patch capable of acquiring high-quality, co-located EEG and fNIRS signals. This patch is wearable and provides easy cognition and emotion detection, while reducing the spatial interference and signal crosstalk by integration, which leads to high spatial-temporal correspondence and signal quality. The modular design of the EEG-fNIRS acquisition unit and optimized mechanical design enables the patch to obtain EEG and fNIRS signals at the same location and eliminates spatial interference. The EEG pre-amplifier on the electrode side effectively improves the acquisition of weak EEG signals and significantly reduces input noise to 0.9 µVrms, amplitude distortion to less than 2%, and frequency distortion to less than 1%. Detrending, motion correction algorithms, and band-pass filtering were used to remove physiological noise, baseline drift, and motion artifacts from the fNIRS signal. A high fNIRS source switching frequency configuration above 100 Hz improves crosstalk suppression between fNIRS and EEG signals. The Stroop task was carried out to verify its performance; the patch can acquire event-related potentials and hemodynamic information associated with cognition in the prefrontal area.