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Tau proteins and senescent Cells: Targeting aging pathways in Alzheimer's disease.
Singh, Mahaveer; Ali, Haider; Renuka Jyothi, S; Kaur, Irwanjot; Kumar, Sachin; Sharma, Naveen; Siva Prasad, G V; Pramanik, Atreyi; Hassan Almalki, Waleed; Imran, Md.
  • Singh M; School of Pharmacy and Technology Management, SVKMs NMIMS University, Shirpur campus, Maharastra India.
  • Ali H; Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan.
  • Renuka Jyothi S; Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
  • Kaur I; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan-303012, India.
  • Kumar S; NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, India.
  • Sharma N; Chandigarh Pharmacy College, Chandigarh Group of College, Jhanjeri, Mohali 140307, Punjab, India.
  • Siva Prasad GV; Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh 531162, India.
  • Pramanik A; School of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, India.
  • Hassan Almalki W; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. Electronic address: whmalki21@gmail.com.
  • Imran M; Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia; Center for Health Research, Northern Border University, Arar, Saudi Arabia.
Brain Res ; : 149165, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-39155034
ABSTRACT
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by abnormal accumulation of tau proteins and amyloid-ß, leading to neuronal death and cognitive impairment. Recent studies have implicated aging pathways, including dysregulation of tau and cellular senescence in AD pathogenesis. In AD brains, tau protein, which normally stabilizes microtubules, becomes hyperphosphorylated and forms insoluble neurofibrillary tangles. These tau aggregates impair neuronal function and are propagated across the brain's neurocircuitry. Meanwhile, the number of senescent cells accumulating in the aging brain is rising, releasing a pro-inflammatory SASP responsible for neuroinflammation and neurodegeneration. This review explores potential therapeutic interventions for AD targeting tau protein and senescent cells, and tau -directed compounds, senolytics, eliminating senescent cells, and agents that modulate the SASP-senomodulators. Ultimately, a combined approach that incorporates tau-directed medications and targeted senescent cell-based therapies holds promise for reducing the harmful impact of AD's shared aging pathways.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article