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Success Rate of Fiducial Markers Placement for Treatment of Esophageal or Rectal Cancers, a prospective multicenter study (FIDECHO study).
Camus, Marine; Karsenti, David; Levy, Jonathan; Moreno, Maira; Coron, Emmanuel; Esch, Anouk; Williet, Nicolas; Wangermez, Marc; Koch, Stéphane; Valats, Jean Christophe; Pioche, Mathieu; Becq, Aymeric; Vanbiervliet, Geoffroy; Audureau, Etienne; Huguet, Florence; Chaput, Ulriikka.
  • Camus M; Centre d'endoscopie digestive, Hôpital Saint Antoine, APHP, Paris, France; Sorbonne Université, Paris, France.
  • Karsenti D; Unité d'Endoscopie Digestive, Pôle Digestif Paris Bercy, Clinique Paris-Bercy, Charenton-le-Pont, France.
  • Levy J; Clinique des Cèdres, Ramsay Santé, Cornebarrieu, France.
  • Moreno M; Commission recherche et développement, Société Française d'Endoscopie Digestive, Paris, France.
  • Coron E; Service d'hépato-gastroentérologie, CHU de, Nantes, France.
  • Esch A; Service de gastroentérologie, Hôpital de la Croix Saint Simon, Paris, France.
  • Williet N; Département d'hépato-gastroentérologie et d'oncologie gastro-intestinale, Institut universitaire de cancérologie et d'hématologie de Saint Etienne (ICHUSE), Unité de recherche ciblée en oncologie (URCAS), CHU de Saint Etienne, Saint-Priest-en-Jarez, France.
  • Wangermez M; Service d'hépato-gastroentérologie, CHU Poitiers, France.
  • Koch S; Service d'hépato-gastroentérologie, CHU de Besançon, France.
  • Valats JC; Service d'hépato-gastroentérologie, CHU de Montpellier, France.
  • Pioche M; Unité d'Endoscopie, pavillon L, Hôpital Édouard Herriot, hospices civils de Lyon France.
  • Becq A; Paris Est Créteil University, Gastroenterology department, APHP, Henri Mondor Hospital, Créteil, France.
  • Vanbiervliet G; Hôpital L'Archet 2, Service de Gastroentérologie, CHU, Nice, France.
  • Audureau E; Service de Santé Publique, Hôpital Mondor, APHP, Paris, France.
  • Huguet F; Sorbonne Université, Paris, France; Service d'Oncologie Radiothérapie, Hôpital Tenon, APHP, Paris, France.
  • Chaput U; Centre d'endoscopie digestive, Hôpital Saint Antoine, APHP, Paris, France. Electronic address: ulriikka.chaput@aphp.fr.
Gastrointest Endosc ; 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39173781
ABSTRACT
BACKGROUND AND STUDY

AIMS:

Endoscopy Ultra-Sound (EUS)-guided fiducial marker placement in patients with esophageal or rectal cancer who have been referred for radiation therapy lacks data regarding its feasibility and safety. The aim of this study was to assess the success rate of EUS-guided fiducial marker placement in these indications. PATIENTS AND

METHODS:

This prospective multicenter study enrolled patients with rectal or esophageal tumor, who were treated between March 2017 and June 2021. The primary endpoint was the success of fiducial markers placement under EUS guidance utilizing the preloaded 22-gauge EchoTip Ultra Fiducial needle® (Cook Medical, Limerick, Ireland), defined by the ability to release fiducials at least at proximal and distal ends of the tumor. The secondary endpoints were the adverse events, length of procedure, and remaining fiducial markers throughout radiation therapy.

RESULTS:

A total of 33 patients were included in this study, with a mean age of 64.2 years ±11.3, and 66.7% of males. Twenty patients had rectal adenocarcinoma, and 13 had esophageal malignancies. The success rate of fiducial markers placement was 93.9%. Markers could only be released at the proximal end of the tumor in two cases. The average procedure time (±SD) was 12.5 min (±4.8). The number of fiducial markers placed for each patient was 3.8 (±0.5). No adverse event was reported. At the end of radiotherapy, markers were still visible on imaging in all patients.

CONCLUSION:

This prospective multicenter study highlights the safety and high success of the placement of fiducial markers under EUS, for rectal and esophageal tumors, without adverse event, and with a short procedure time. Fiducial markers remain in place over time during radiation therapy. CLINICALTRIALS gov ID NCT03057288.

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article