Therapeutic potential of xtr-miR-22-3p from Plastrum testudinis in acute promyelocytic leukemia.
J Asian Nat Prod Res
; : 1-13, 2024 Sep 11.
Article
en En
| MEDLINE
| ID: mdl-39258746
ABSTRACT
Acute promyelocytic leukemia (APL) is marked by a block at the promyelocyte stage. Treatments like ATRA and ATO face resistance and relapse issues. Plastrum testudinis, a traditional Chinese medicine, may offer therapeutic potential. This study investigated xtr-miR-22-3p from P. testudinis for treating APL. High expression of xtr-miR-22-3p was confirmed, with target prediction indicating interactions with key genes, including PML. xtr-miR-22-3p reduced HL-60 leukemia cell growth, altered the cell cycle, and selectively inhibited HL-60 proliferation while promoting BMSC growth, suggesting its potential as a targeted APL therapy.
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2024
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