Regulation of immune responses to food by commensal microbes.
Immunol Rev
; 326(1): 203-218, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39285525
ABSTRACT
The increasing prevalence of immune-mediated non-communicable chronic diseases, such as food allergies, has prompted a deeper investigation into the role of the gut microbiome in modulating immune responses. Here, we explore the complex interactions between commensal microbes and the host immune system, highlighting the critical role of gut bacteria in maintaining immune homeostasis. We examine how modern lifestyle practices and environmental factors have disrupted co-evolved host-microbe interactions and discuss how changes in microbiome composition impact epithelial barrier function, responses to food allergens, and susceptibility to allergic diseases. Finally, we examine the potential of bioengineered microbiome-based therapies, and live biotherapeutic products, for reestablishing immune homeostasis to prevent or treat food allergies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Simbiosis
/
Microbioma Gastrointestinal
/
Hipersensibilidad a los Alimentos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article