New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.
Cancer Treat Rep
; 69(5): 551-3, 1985 May.
Article
en En
| MEDLINE
| ID: mdl-4005878
ABSTRACT
In an extension of our prior studies in murine tumor models, we examined two new folate analogs in the 10-deaza-aminopterin series for antitumor activity against a group of human tumor xenografts in nude mice. In all three xenograft models studied, MX-1 mammary carcinoma, LX-1 lung carcinoma, and CX-1 colon carcinoma, 10-deaza-aminopterin was minimally active, while methotrexate was inactive. In contrast, against the MX-1 and LX-1 tumors, 10-ethyl, 10-deaza-aminopterin at or near the LD10 dose (2-4.5 mg/kg) given once per day X 5 produced frank regressions. Activity of this analog against the CX-1 tumor was less, but retardation of tumor growth was observed with some minor regressions.
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Banco de datos:
MEDLINE
Asunto principal:
Metotrexato
/
Antagonistas del Ácido Fólico
/
Aminopterina
/
Neoplasias Experimentales
/
Antineoplásicos
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Año:
1985
Tipo del documento:
Article