Effect of long-term hormonal contraception on plasma lipids.

ABSTRACT

PIP: Serum lipid and apoprotein levels were determined in fasting women after longterm use (5-12 years) of Depo-Provera, Orgametril, Ortho Novum SQ, Binordiol, Microgynon-50, and Ministat. Compared with matched controls, pure progestogens (Depo-Provera and Orgametril) caused a moderate decrease of triglycerides (TG), HDL cholesterol, and Apo Al, whereas estrogen-dominant oral contraceptives (Ortho Novum SQ) increased the same parameters. The effects of longterm use of hormonal contraception on lipids did not differ from those predicted from short-term (6 months) studies.