2',3'-Bis(2-chloroethyl)aminophosphoryl-3'-amino-3'-deoxyadenosine: a cyclic nucleotide with antitumor activity.
J Med Chem
; 22(7): 882-5, 1979 Jul.
Article
en En
| MEDLINE
| ID: mdl-448687
ABSTRACT
The synthesis of the title compound from 3'-amino-3'-deoxyadenosine in 40% yield is reported. 3'-Amino-3'-deoxyadenosine was made by an improved synthesis in 12 steps from inexpensive D-xylose in 15% overall yield. Both isomers of the title compound, separated by column chromatography, possess confirmed activity against KB tumor cell cultures.
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Banco de datos:
MEDLINE
Asunto principal:
Mostazas de Fosforamida
/
Nucleótidos de Desoxiadenina
/
Nucleótidos Cíclicos
Límite:
Animals
/
Humans
Idioma:
En
Año:
1979
Tipo del documento:
Article