Effects of diethylcholine in two animal models of Parkinsonism tremors.
Eur J Pharmacol
; 56(1-2): 159-62, 1979 Jun.
Article
en En
| MEDLINE
| ID: mdl-467505
ABSTRACT
(2-Hydroxyethyl) methyldiethylammonium iodide (diethylcholine; DEC) was tested against trihexyphenidyl for its ability to block tremors in two animal models of Parkinsonism tremors. Both DEC (75 mg/kg) and trihexyphenidyl (10 mg/kg) antagonized physostigmine tremors in mice. Both drugs also blocked tremors in rats which received intracaudate injections of carbachol. DEC was more efficacious than trihexyphenidyl in the rat model. No dose-related inhibition of tremors was seen for trihexyphenidyl (5--20 mg/kg) but inhibition by DEC was dose-related (25--50 mg/kg). The ED50 for tremor inhibition in the rat model by DEC was 33 mg/kg. DEC was also shown to cross the blood-brain barrier in mice. The probable mechanism of action of DEC is discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson Secundaria
/
Colina
Límite:
Animals
Idioma:
En
Año:
1979
Tipo del documento:
Article