Cefamandole kinetics in uremic patients undergoing hemodialysis.
Clin Pharmacol Ther
; 26(5): 592-9, 1979 Nov.
Article
en En
| MEDLINE
| ID: mdl-498702
ABSTRACT
A single intravenous 15 mg/kg dose of cefamandole was given to 6 patients in chronic renal failure before hemodialysis, and 3 were examined during an interdialysis period. Mean cefamandole clearance by hemodialysis was 24 +/- 12 ml/min; 35 +/- 15% of the dose was recovered in the dialysate. The cefamandole half-life (1 1/2) on dialysis was 4.0 +/- 0.29 hr; off dialysis it was 13.9 +/- 4.2 hr. High urine concentrations of cefamandole in these patients suggests usefulness in urinary tract infection.
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Banco de datos:
MEDLINE
Asunto principal:
Uremia
/
Cefamandol
/
Cefalosporinas
/
Diálisis Renal
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1979
Tipo del documento:
Article