Purified human fibroblast interferon in vivo: skin reactions and effect on bone marrow precursor cells.
Cancer Lett
; 7(5): 243-9, 1979 Sep.
Article
en En
| MEDLINE
| ID: mdl-509407
ABSTRACT
Human interferon from normal diploid fibroblasts, purified by sequential chromatography on concanavalin A-agarose and phenyl-sepharose, was administered parenterally in 4 subjects. Fever, marked skin hypersensitivity reactions and suppression of marrow stem cells (estimated by the count of myeloid colony-forming cells), side-effects common for less purified fibroblast and leukocyte interferons, were absent. Purified fibroblast interferon retained antiviral and immunomodulatory activity, evidenced by reduction of the blastogenic response of peripheral lymphocytes and decrease of hepatitis B virus markers in a patient with chronic hepatitis B infection treated with this substance.
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Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Células Madre Hematopoyéticas
/
Interferones
/
Fibroblastos
Límite:
Humans
Idioma:
En
Año:
1979
Tipo del documento:
Article