HLA types and immunity in multiple sclerosis.
Neurology
; 29(12): 1561-5, 1979 Dec.
Article
en En
| MEDLINE
| ID: mdl-574218
ABSTRACT
HLA types and levels of humoral and cell-mediated immune responses to several antigens were studied in a large group of patients with multiple sclerosis, and in controls. Patients were more likely than controls to have the DRw2 antigen. They had higher mean antibody titers to measles but not to cytomegalovirus, herpes 1, or herpes 2, and had less competent cell-mediated responses. Antibody titers to measles were lower and cell-mediated immune responses were more effective in patients with the DRw2 antigen in patients than in patients without it. This apparent specificity for measles suggests that the etiology of multiple sclerosis is related to the immune response to measles or related viruses.
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Banco de datos:
MEDLINE
Asunto principal:
Antígenos HLA
/
Esclerosis Múltiple
Límite:
Female
/
Humans
/
Male
Idioma:
En
Año:
1979
Tipo del documento:
Article