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Effects of actinomycin D on brain RNA synthesis and discrimination learning in the goldfish (Carassius auratus).
Physiol Behav ; 19(2): 261-4, 1977 Aug.
Article en En | MEDLINE | ID: mdl-607238
Intracranial injection of actinomycin D 2 microgram inhibited about 70% of the brain RNA synthesis from 3 hr to 4 days after injection in the goldfish. Under these conditions, fish were given 4-day-training of visual discrimination between a card with vertical stripes and one with horizontal stripes. Fish injected intracranially with actinomycin D showed deficits in between-day retention (long-term memory) but not interruption of within-day acquisition (short-term memory). It is suggested that brain RNA synthesis is necessary only for the formation of long-term memory but not short-term memory.
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Banco de datos: MEDLINE Asunto principal: Encéfalo / ARN / Dactinomicina / Aprendizaje Discriminativo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 1977 Tipo del documento: Article
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Banco de datos: MEDLINE Asunto principal: Encéfalo / ARN / Dactinomicina / Aprendizaje Discriminativo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 1977 Tipo del documento: Article