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Effects of perinatal exposure of Wistar rats to l-alpha-acetylmethadol.HCl on hepatic microsomal mixed-function oxidase enzyme activity in the adult.
Drug Metab Dispos ; 10(1): 74-6, 1982.
Article en En | MEDLINE | ID: mdl-6124388
ABSTRACT
I-alpha-Acetylmethadol (LAAM) was administered via the drinking water to female Wistar rats throughout pregnancy and lactation. Controls were pair-fed and watered. After weaning, pups received lab chow and water ad lib. until maturity. The apparent KM and Vmax were determined for benzo[a]pyrene hydroxylase (BPH), aminopyrine N-demethylase (AP), ethylmorphine N-demethylase (ET) and aniline hydroxylase (AN) from the hepatic microsomal fraction of the mature male and female offspring. The dose of LAAM administered was low enough to produce no symptomatology. In the adult male, pre- and neonatal exposure to LAAM resulted in decreases in KM for AP and Vmax for AN, and increase in the KM and Vmax for BPH. For the female, LAAM produced an increase in KM for AP and a decrease in Vmax for ET and BPH. That is, long-term changes occurred in the enzyme parameters measured; the direction of the changes were sex- and substrate-dependent.
Asunto(s)
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Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Efectos Tardíos de la Exposición Prenatal / Microsomas Hepáticos / Oxigenasas de Función Mixta / Metadona / Acetato de Metadil Límite: Animals / Pregnancy Idioma: En Año: 1982 Tipo del documento: Article
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Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Efectos Tardíos de la Exposición Prenatal / Microsomas Hepáticos / Oxigenasas de Función Mixta / Metadona / Acetato de Metadil Límite: Animals / Pregnancy Idioma: En Año: 1982 Tipo del documento: Article