Antitrypanosomal activity of sinefungin.
Am J Trop Med Hyg
; 32(1): 31-3, 1983 Jan.
Article
en En
| MEDLINE
| ID: mdl-6130709
ABSTRACT
Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5' of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense. Anti-trypanosomal activity of sinefungin could be the result of the inhibition of transmethylation reactions or of polyamine biosynthesis--or both--in parasites.
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Banco de datos:
MEDLINE
Asunto principal:
Tripanosomiasis Africana
/
Adenosina
Límite:
Animals
Idioma:
En
Año:
1983
Tipo del documento:
Article