Hypnotic action of benzodiazepines: a possible mechanism.
Life Sci
; 34(18): 1763-8, 1984 Apr 30.
Article
en En
| MEDLINE
| ID: mdl-6145073
ABSTRACT
The objective of this investigation was to determine whether the effects of muscimol on benzodiazepine receptor binding relate to the hypnotic activity of nine benzodiazepines (clonazepam, triazolam, diazepam, flurazepam, nitrazepam, oxazepam, temazepam, clobazam, and chlordiazepoxide) and CL 218,872. There was no correlation between the basal receptor binding affinities of the drugs tested and their hypnotic potencies, whereas the benzodiazepine receptor agonists whose receptor bindings are strongly modulated by muscimol possess potent hypnotic activity. These results indicate that benzodiazepine receptors that couple to GABA receptors are involved in the hypnotic activity of the benzodiazepines.
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Banco de datos:
MEDLINE
Asunto principal:
Oxazoles
/
Ansiolíticos
/
Receptores de Superficie Celular
/
Hipnóticos y Sedantes
/
Muscimol
Límite:
Animals
Idioma:
En
Año:
1984
Tipo del documento:
Article