[Model of the defense reaction in rats to study the antifenamine effect of neuroleptics for demonstrating their specific action]. / Izuchenie na modeli oboronitel'noi reaktsii u krys antifenaminovogo éffekta neiroleptikov dlia vyiavleniia ikh spetsificheskogo deistviia.

ABSTRACT

The authors studied the ability of neuroleptics to eliminate the amphetamine-induced (5 mg/kg) disorders of the transformation of the defense response trajectory in rats kept in a U-shaped maze. Haloperidol (0.1 mg/kg) and clozapine (2 mg/kg) similarly normalized the animals' behavior but differently affected the motor automatisms typical for amphetamine stereotypy. Metoclopramide (1 mg/kg) reduced the external manifestations of amphetamint stereotypy but did not abolish the disorders in the defense response. It is likely that the ability of the neuroleptics to produce an antiamphetamine action in experimental defense response with multiple transformation of the responses might characterize specific properties of the drugs belonging to the class under discussion.