Binding of chlormadinone acetate to cytosol from human benign prostatic hypertrophy.
Endocrinol Jpn
; 27(1): 53-7, 1980 Feb.
Article
en En
| MEDLINE
| ID: mdl-6156069
ABSTRACT
Chlormadinone acetate was bound to cytosol from the human benign prostatic hypertrophy in a high affinity fashion. The kd and number of maximum binding site of the binding were 5.4 +/- 0.7 X 10(-9) M and 67.9 +/- 5.8 fmol/mg protein, respectively. When compared with the binding to dihydrotestosterone, the Kd for chlormadinone acetate was greater. The number of maximum binding site for chlormadinone acetate was observed to be smaller than that for dihydrotestosterone, but these two values were not different statistically. The binding of chlormadinone acetate was inhibited significantly by the addition of R 1881 or cyproterone acetate. However, dihydrotestosterone revealed itself to be a weak inhibitor of the binding. The cytosol prelabelled with chlormadinone acetate was not bound to the nuclei of the human prostate.
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Banco de datos:
MEDLINE
Asunto principal:
Hiperplasia Prostática
/
Acetato de Clormadinona
/
Citosol
Límite:
Humans
/
Male
Idioma:
En
Año:
1980
Tipo del documento:
Article